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This study investigated the ability of the exogenous steroidal derivative, 11alpha-methyl-9alpha,11beta-epoxy-5alpha-androstane-3,17-dione (11alpha-methyl-11-oxo-5alpha-androstane-3,17-dione, 11-oxo), to modify various aspects of reproductive steroid synthesis. The effects of this agent on plasma steroid levels, basal and luteinizing hormone (LH)-stimulated levels of delta 4-5alpha-reductase (DHRS4) and aromatase expression were investigated in the immature female rat. In addition, the ability of 11alpha-methyl-11-oxo-5alpha-androstane-3,17-dione to alter the anabolic state of the uterus and liver by altering steroid production was evaluated. The results indicate that the 11-oxo derivative can up-regulate, androstenedione and testosterone biosynthesis via DHRS4 and aromatase, respectively. The activities of these enzymes appear to vary between the sexes, and in the liver of the female this steroid may enhance androgen production by blocking conversion to estrogens. It is concluded that 11alpha-methyl-11-oxo-5alpha-androstane-3,17-dione has the potential to up-regulate steroidogenesis
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